How do comedians know what to say next?

How do comedians know what to say next? It's the thing they say after that that kills, I find. The followup, or if there's a sufficient lag between setup and payoff: The CALLBACK.  

Do screenwriters and novelists have better dreams? Better-plotted? More realistic? 

Doubt it. Still, after that last strike I think most of us who rely on others'-written entertainments are willing to toss a couple dice at it. See which die cracks! 

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