"Hi, I'm film and television actor Bradley Cooper. You know, tight pants aren't just unsightly and uncomfortable. They are proven to lower sperm counts, and could even be a link to increased risk of testicular cancer. DON'T BE A DICK TO YOUR BALLS."
There are a couple potential problems with this pitch, but I think if we can get Bradley Cooper those problems go away pretty much. It'd be a short, punchy spot. Get in, get to the catchphrase, get out. Arguably Bradley Cooper's not the best pick for this, as he's been quite a tight pants wearer himself, but in my belief it's always been in the service of the role. Anyway, a converted former offender can be a convincing pitchman.
People might object that the testicular cancer link isn't established or supported by anything in the research. This is probably true, but I needed two medical-sounding things. Besides, I softened it quite a bit with that "and could even be a link" bit. Nobody's saying any link has been proved. But if we can get these poor tight-pants culture victims to loosen up a bit and look less ridiculous, the ends justify the means to some extent do they not?
Really I just wanted a reason for the "Don't be a dick to your balls" slogan. That could easily catch on.